
I haven’t found anything personally that I want to play that I can’t play as I play a lot of indie games and singleplayer games. Proton is pretty incredible. YMMV though. If you play games that heavily rely on mouse and keyboard and twitch reflexes, or any game that has strict anti-cheat/DRM, you might have a suboptimal experience or not be able to play it at all.

I know a lot of women who have played sim/management games like The Sims, Zoo Tycoon, Stardew Valley, etc.
A lot of this comes down to the actual survey questions that were used. If the wording of the survey questions was “Have you ever played…” as opposed to “Do you regularly play…” for example, then the numbers could be quite skewed.
Weapons, armor, equipment, upgrades, etc. in single-player games that have effects that have tradeoffs or very niche use-cases are unfun. I can understand it in multiplayer competitive games where balance is important, but effects like “provides 20% more defense versus <specific enemy type>” or “increases range, but decreases damage” just deflate me when I get them in games. If I’m spending time playing a game, I want to earn things that make me objectively better as I progress. Developers of modern games seem waaay to preoccupied with holding back and not allowing things to be “broken” in games where it just doesn’t matter.
Civ V/Civ VI can all be played entirely with a mouse. Very fun, too.